Business
- Dave Thomas - Founder, Wendy's
- Kent "Oz" Nelson- Retired CEO & Chairman, United Parcel Service
- William Schreyer - Retired CEO & Chairman, Merrill Lynch & Co.
- Curt Carlson - Founder, Carlson Companies - TGI Friday's, Radisson Hotels
- Dr. James Naismith - Inventor of Basketball
- Orel Hershiser - Pitcher, Los Angeles Dodgers, 1988 Cy Young Award Winner
- Richard J. Gannon - Quarterback, Oakland Raiders, 2002 NFL MVP
- Bill Brown - Pro Bowl Running Back, Minnesota Vikings
- Bill Doba - Head Football Coach, Washington State University
- Sean Casey - First Baseman, Boston Red Sox
- Keith Moreland - Outfielder, Chicago Cubs
- Roy Riegels - Rose Bowl Hall of Fame
- Davey O'Brien - Quarterback, Texas Christian University, 1938 Heisman Trophy winner
- Johnny Robinson - All-Time All-AFL Team Strong Safety, Kansas City Chiefs
- Alvin F. Rylander - Olympic Crew, 1928 gold medalist
- Alma Richards - Olympic High Jumper, 1912 gold medalist
- Dallas Long - Olympic Shot Putter, 1960 silver medalist & 1964 gold medalist
- J.C. Snead - professional golfer
- Bob Todd - baseball coach, Ohio State University
- Bill Cubit - head football coach, Western Michigan University
- James T. Conway - General, United States Marine Corps
- James D. Latham - General, United States Air Force
- Anthony C. McAuliffe - General, United States Army (WWII)
- Kiffin Rockwell - first American to score victory in aerial combat
- Iven C. Kincheloe, Jr. - Captain, United States Air Force (Korean War), first to fly above 100,000 feet
- Douglas Engelbart - inventor of the computer mouse
- Karol Bobko - NASA space shuttle commander
- Drew Feustel - NASA astronaut
- Steve Altes - aerospace engineer
- David Coleman - "The Dating Doctor" - Inspiration for the movie and title character "Hitch"
- Theodore S. "Dr. Seuss" Geisel - Author
- Tim Mahoney - Guitarist for the band 311
- John Goodman - Actor
- James McDaniel - Emmy Award-winning TV and film actor
- Steve Hofstetter - Comedian/Radio Personality
- Marc Blucas - Actor
- Andy Richter - Actor
- Carroll O'Connor - Actor - most renowned for playing Archie Bunker on the hit '70s TV show, "All in the Family"